PhD student profile, Stefano Bernardi

PhD Student:  Stefano Bernardi

Tutor: Prof. Patrizia Riso, DeFENS

Dean: Prof. Francesco Bonomi

Research area: Food Science and Nutrition

 

Research topic

Protective role of polyphenol-rich diet in subjects with dysfunctional intestinal barrier and evaluation of dietary bioactives main mechanisms of action

 

Project Synopsis

My PhD project will focus on a dietary intervention study in a group of older people with dysfunctional intestinal barrier living in a controlled setting. The aim is to develop and demonstrate that a polyphenol-rich diet can exert benefits in this target population by reducing intestinal permeability and the inflammatory processes generally associated. This protective effect may be mediated by an improvement of gut microbiota composition; in addition, a direct and indirect (through derived metabolites) effect of polyphenols at the intestinal and systemic level is not excluded. In this context, markers of oxidative stress including DNA damage, endothelial function and other variables related with health and well-being will be investigated. Moreover, it is expected that the regular intake of the polyphenol-rich diet will induce a favourable metabolic and functional phenotype in the elderly.

 

Project keywords

older people, intestinal permeability, polyphenols, inflammaging

 

Contacts

DeFENS – Department of Food, Environmental and Nutritional Sciences

Division of Human Nutrition

Università degli Studi di Milano

Via Celoria 2, 20133  Milano, Italy

Phone: +39 02 50316728   Fax: +39 02 50316721

e-mail: stefano.bernardi@unimi.it

Skype: sbnutrifood

 

Collaborations

Prof. Cristina Andrés Lacueva – University of Barcelona, Nutrition, Food Science and Gastronomy Department, Biomarkers and Nutrimetabolomics Laboratory, Barcelona, Spain

Dr. Paul Kroon – Institute of Food Research, Norwich Research Park, Norwich, UK

Chiara Cavazzini – Civitas Vitae-OIC Foundation nursing home, Padova, Italy.

 

Sponsor

Fellowship sponsor: Università degli Studi di Milano

 

Scientific Publications

Campolo J, De Maria R, Cozzi L, Parolini M, Bernardi S, Proserpio P, Nobili L, Gelosa G, Piccolo I, Agostoni E.C, Trivella M.G, Marraccini P. Antioxidant and inflammatory biomarkers for the identification of prodromal Parkinson’s disease; Journal of the Neurological Sciences 370 (2016) 167–172; DOI: 10.1016/j.jns.2016.09.050

 

Scientific communication to congress

Campolo J, Bernardi S, Cozzi L, Caruso R, Dellanoce C, Tonini , Parolini M, De Chiara B, Micheloni G, Giannattasio C, Parodi O, – “Medium term effect of sublingual L-glutathione (L-GSH) supplementation on flow-mediated dilation and oxidative stress markers in subjects with cardiovascular risk factors” – 75° congresso nazionale Società Italiana di Cardiologia – Roma 13 – 15 dic 2014 [Poster presentation]

Campolo J, Bernardi S, Cozzi L, Caruso R, Dellanoce C, Tonini, Parolini M, De Chiara B, Micheloni G, Giannattasio C, Parodi O, – “Medium-term effect of sublingual L-glutathione supplementation on flow- mediated dilation and oxidative stress markers in male subjects with cardiovascular risk factors” – 17th International Symposium on Atherosclerosis – ISA 2015 Amsterdam. [Oral presentation]

 

Others

 

Education

Secondary School: I.T.I.S. Galileo Galilei Crema – Food technology – 2005

Graduate School:

University of Milan – Bachelor Degree in Biomedical laboratory techniques -2008.

University of Milan – Master Degree in Human Nutrition -2014

University of Parma – Qualification as a Professional Biologist – 2014

 

Other research collaborations

CNR Institute of Clinical Physiology, ASST; Great Metropolitan Hospital Niguarda, Milan, Italy:

• DOREMI European project -Fp7 – 2015-2016
• Progetto MbMM – Accordo quadro regione Lombardia – Metodologie di base per l’innovazione nella diagnosi e nella terapia di Malattie Multifattoriali – 2015-2016