PhD: Stefano De Benedetti
Tutor: Prof. Francesco Bonomi – DeFENS
Dean: Prof. Francesco Bonomi
Research area: Chemistry and Biochemistry
PhD title achieved on: 4th April 2017
Research topic
Multidisciplinary studies of complex human diseases: from nutrition to molecular biology
Project Synopsis
Multidisciplinary study of a geographic cluster of Sporadic Amyotrophic Lateral Sclerosis patients, with proteomic, metallomic, genetic and advanced multifactorial statistical analyses. The project is aimed at studying the different aspects of the disease with a particular focus to nutrition and environmental exposure. The final outcome would lead to a better understanding of the disease, by studying subjects exposed to common environmental stressors, and to propose potential nutritional interventions to manage the disease course.
Project keywords
environment, complex diseases, proteomics, metals
Contacts
DeFENS – Division of Chemical and Biomolecular Sciences
Via Celoria 2, 20133 Milano – Italy
Phone: +39 02 503 16823
E-mail: stefano.debenedetti@unimi.it
Collaborations
Prof. Elisabetta Gianazza, Laboratory of Biochemistry and Computational Biophysics, Department of Pharmacological and Biomolecular Sciences (DiSFeB), via G. Balzaretti 9, University of Milan, 20133 Milano, Italy.
Dott.ssa Silvana Penco, Medical Genetics Unit, Department of Laboratory Medicine, Niguarda Ca’ Granda Hospital, 20169, Milan, Italy.
Sponsor
Fellowship sponsor: Università degli Studi di Milano
Project sponsor: Comitato per la Fondazione Giovanni Raffo – Onlus (partially funding – recruitment of patients)
Publications
Stefano De Benedetti, Giorgio Lucchini, Alessandro Marocchi, Silvana Penco, Christian Lunetta, Stefania Iametti, Elisabetta Gianazza, Francesco Bonomi. Serum metal evaluation in a small cohort of Amyotrophic Lateral Sclerosis patients reveals high levels of thiophylic species. Peptidomics. Volume 2, Issue 1, ISSN (Online) 2084-7203, DOI: 10.1515/ped-2015-0004, January 2016
M.S. Cigoli, S. De Benedetti, A. Marocchi, S. Bacigaluppi, P. Primignani, G. Gesu, A. Citterio, L. Tassi, O. Mecarelli, P. Pulitano, S. Penco. A novel MGC4607/CCM2 gene mutation associated with cerebral spinal and cutaneous cavernous angiomas. J Mol Neurosci July 2015, Volume 56, Issue 3, pp 602-607. doi: 10.1007/s12031-015-0555-0
Cigoli MS, Avemaria F, De Benedetti S, Gesu GP, Accorsi LG, Parmigiani S, Corona MF, Capra V, Mosca A, Giovannini S, Notturno F, Ciccocioppo F, Volpi L, Estienne M, De Michele G, Antenora A, Bilo L, Tavoni A, Zamponi N, Alfei E, Baranello G, Riva D, Penco S. PDCD10 gene mutations in multiple cerebral cavernous malformations. PLoS One. 2014 Oct 29;9(10):e110438. doi: 10.1371/journal.pone.0110438. eCollection 2014
XIV FISV congress. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. A multidisciplinary approach to study Sporadic Amyotrophic Lateral Sclerosis in patients with common geographical origin. Poster
XXI Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Sporadic Amyotrophic Lateral Sclerosis in patients with common geographical origin: a multidisciplinary study. Oral presentation
FEBS/IUBMB Advanced lecture course Spetses 2016 “Molecular basis of human diseases: 50 years’ anniversary of Spetses summer schools”. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. Serum metal concentrations and proteomics of ALS patients originating from a small geographical area. Poster
ENCALS Meeting 2016. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi. Metal and proteomic analysis of sporadic ALS patients with common geographical origin. Poster
XVIII Congresso Nazionale Società Italiana di Genetica Umana, SIGU 2015. De Benedetti, G. Lucchini, A. Marocchi, C. Lunetta, S. Iametti, E. Gianazza, F. Bonomi, S. Penco. Metals concentrations in Amyotrophic Lateral Sclerosis patients originating from a restricted geographical area. Poster
XX Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Metals and proteomics of the biological fluids in ALS patients: Preliminary data. Poster
IUBMB Symposium FeS 2015. Iron Sulfur Cluster Biogenesis and Regulation. De Benedetti, G. Lucchini, A. Marocchi, S. Penco, S. Iametti, E. Gianazza, F. Bonomi. Metals analysis in a small cohort of ALS patients originating from a restricted geographical area: preliminary data. Poster
XIX Workshop on the Developments in the Italian PhD Research on Food Science, Technology and Biotechnology. Micronutrients in a Neurodegenerative Disorder such as Amyotrophic Lateral Sclerosis. Poster
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