PhD student profile, Luce Micaela Mattio

PhD Student: Luce Micaela Mattio


Tutor: Prof. Sabrina Dallavalle – DeFENS

Dean: Prof. Ella Pagliarini

Research area: Chemistry and Biochemistry

Research topic: Sustainable chemistry for the preparation of molecules of agri-food interest


Project Synopsis

My PhD project is focused on the preparation of polyphenolic compounds, in particular stilbenoids (resveratrol analogues and dimers) and flavonoids (anthocyanidins, chalcons) and their metabolites. The desired compounds will be obtained by synthetic and biocatalytic methodologies and/or by purification procedures from selected raw materials. These molecules will be tested for their activity (antioxidant properties, immunomodulatory functions, etc) in different biological models and for their interactions with the microbiota. Structure-activity relationship studies will be performed in order to understand the modes of action of the active compounds. Moreover, new polyphenol derivatives will be designed, synthetized and evaluated for antibacterial and antifungal activity.


Project keywords

Chemical synthesis, biocatalysis, polyphenols, by-product


Contacts Department of Food, Environmental and Nutritional Sciences (DeFENS) – Via Celoria 2, 20133 Milano



Prof. Andrea Pinto, Department of Food, Environment and Nutritional Sciences, UNIMI

Prof. Diego Romano, Department of Food, Environment and Nutritional Sciences, UNIMI

Prof. Alessandra Marti, Department of Food, Environment and Nutritional Sciences, UNIMI

Valentina Taverniti, Department of Food, Environment and Nutritional Sciences, UNIMI

Prof. Francesco Bonomi, Prof. Stefania Iametti, Prof. Alessio Scarafoni, Department of Food, Environment and Nutritional Sciences, UNIMI

Dr. Stefania Arioli, Department of Food, Environment and Nutritional Sciences, UNIMI

Prof. Jan Frederik Stevens, Linus Pauling Institute, Oregon State University



Fellowship sponsor: Università degli Studi di Milano



L. Mattio, L. Musso, L. Scaglioni, A. Pinto, P. A. Martino, S. Dallavalle (2018) Synthesis of a leopolic acid-inspired tetramic acid with antimicrobial activity against multidrug-resistant bacteria. Beilstein J. Org. Chem. 14, 2482-2487. DOI: 10.3762/bjoc.14.224.

Zuccolo, S. Dallavalle, R. Cincinelli, L. Mattio, S. Mazzini, M. De Cesare, L. Musso (2019) 2-Acryloyl-4,5-methylendioxyphenol: A Small Molecule Endowed with Antidermatophytic Activity. Letters in Drug Design & Discovery 16, 1-6. DOI: 10.2174/1570180815666180803115347

L. Mattio, M. Marengo, C. Parravicini, I. Eberini, S. Dallavalle, F. Bonomi, S. Iametti, A. Pinto (2019) Inhibition of Pancreatic a-amylase by Resveratrol Derivatives: Biological Activity and Molecular Modelling Evidence for Cooperativity between Viniferin Enantiomers. Molecules, 24, 3225. DOI: 10.3390/molecules24183225


Poster and oral communication

L. Mattio, A. Pinto, S. Dallavalle, D. Romano, P. Abbasi Parizad, G. Della Scala (2018) Polyphenols: chemistry, metabolites, and structure-activity relationship studies

Oral presentation at Advanced School on “Food Proteins”, 2-4 May 2018, Bergamo.


L. Mattio, S. Dallavalle (2018) Synthesis and biological evaluation of resveratrol-derivatives

Poster presentation at XXIII Workshop on the developments in the Italian PhD Research on food science, technology and biotechnology, 19-21 September 2018 – Oristano.


L. Mattio, F. Braggio, M. Marengo, A. Scarafoni, S. Iametti, S. Dallavalle, A. Pinto (2018) Structure-dependent biological activities of natural resveratrol derivatives

Poster presentation at CHIMALI – XII Italian Food Chemistry Congress, 24-27 September 2018 – Camerino.


Wu, I. L. Paraiso, L. Mattio, R. Reed, J. Morré, A. F. Gombart. C. S. Maier, J.F. Stevens (2019) Gut microbial and hepatic metabolism of the hop flavonoid xanthohumol in humans

Poster presentation at 67th ASMS Conference on Mass Spectrometry and Allied Topics, 2-6 June, 2019 – Atlanta (GA – USA).


L. Mattio, W. Wu, K. Brown, C. Miranda, A. Vaswani, A. Alcazar Magana, J. Morré, C. S. Maier, J.F. Stevens (2019) Global natural products social molecular networking (GNPS) analysis integrated with model-predicted bioactives in hops extract

Poster presentation at Linus Pauling Institute International Conference 2019, 14-16 August, 2019 – Corvallis (OR – USA).


L. Mattio, W. Wu, I. L. Paraiso, R. Reed, J. Morré, A. F. Gombart, C. S. Maier, J.F. Stevens (2019) Quantitative profiling of urinary xanthohumol metabolites in humans reveals metabotypes that reflect differences in gut microbiomes

Oral presentation at 13rd World Congress on Polyphenols Application, 30th September – 1 October, 2019 – La Valletta, Malta.


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