PhD student profile, Massimiliano Tucci

PhD Student: Massimiliano Tucci (ORCID n. 0000-0001-8693-9577)

Massimiliano Tucci (cycle 35)


Tutor: Prof.ssa Patrizia Riso, DeFENS – Division of Human Nutrition

Dean: Prof. Diego Mora

Research area: Food Science and Nutrition

PhD title achieved on: 20th October 2022


Research topic

Bioavailability and biological activity of dietary compounds/patterns and their role on human health

Project Synopsis

The aim of my project is to provide evidence on the protective role of bioactive-rich foods and dietary patterns in the context of sustainable diets. Specific aims will be the evaluation of the actual bioavailability of food bioactives, their potential biological effects and their role in the promotion of health-related markers (e.g. oxidative stress, inflammation, endothelial and vascular functions, metabolic activity) in specific target groups of population (e.g. older subjects and those with cardiovascular/metabolic risks). In addition, the obtained results will be considered for the development of dietary patterns able to respond to health and sustainability needs in the context of climate change. This will be performed though the exploitation of comprehensive nutritional evaluations (e.g. in terms of nutrients and food bioactives) and possible in vivo validation of the most promising patterns.


Project keywords

Food Dietary patterns, Food bioactives, Health



Department of Food, Environmental and Nutritional Sciences DeFENS -Dipartimento di scienze per gli Alimenti, la Nutrizione e l’Ambiente

Division of Human Nutrition – Sezione di Nutrizione Umana – Via Celoria 2, 20133 Milano




Fellowship sponsor: Università degli Studi di Milano



Del Bo, C., Marino, M., Martini, D., Tucci, M., Ciappellano, S., Riso, P., & Porrini, M. (2019). Overview of Human Intervention Studies Evaluating the Impact of the Mediterranean Diet on Markers of DNA. Nutrients. 2019 Feb 13;11(2). pii: E391. doi: 10.3390/nu11020391. Review.

Del Bo’, C., Bernardi, S., Marino, M., Porrini, M., Tucci, M., Guglielmetti, S., Cherubini, A., Carrieri, B., Kirkup, B., Kroon, P., Zamora-Ros, R., Liberona, N., Andres-Lacueva, C., Riso, P. (2019). Systematic Review on Polyphenol Intake and Health Outcomes: Is there Sufficient Evidence to Define a Healthffi Promoting Polyphenol-Rich Dietary Pattern? 2019 Jun 16;11(6). pii: E1355. doi: 10.3390/nu11061355. Review.

Marino, M.; Bo’, C.D.; Tucci, M.; Klimis-Zacas, D.; Riso, P.; Porrini, M. Modulation of Adhesion Process, E-Selectin and VEGF Production by Anthocyanins and Their Metabolites in an In Vitro Model of Atherosclerosis. Nutrients 2020, 12, 655. Article.

Martini, D.; Bernardi, S.; Del Bo’, C.; Hidalgo Liberona, N.; Zamora-Ros, R.; Tucci, M.; Cherubini, A.; Porrini, M.; Gargari, G.; González-Domínguez, R.; Peron, G.; Kirkup, B.; Kroon, P.A.; Andres-Lacueva, C.; Guglielmetti, S.; Riso, P. Estimated Intakes of Nutrients and Polyphenols in Participants Completing the MaPLE Randomised Controlled Trial and Its Relevance for the Future Development of Dietary Guidelines for the Older Subjects. Nutrients 2020, 12, 2458. Article.

Tucci, M.; Martini, D.; Del Bo’, C.; Marino, M.; Battezzati, A.; Bertoli, S.; Porrini, M.; Riso, P. An Italian-Mediterranean Dietary Pattern Developed Based on the EAT-Lancet Reference Diet (EAT-IT): A Nutritional Evaluation. Foods 2021, 10, 558. Article.

Martini, D.; Tucci, M.; Bradfield, J.; Di Giorgio, A.; Marino, M.; Del Bo’, C.; Porrini, M.; Riso, P. Principles of Sustainable Healthy Diets in Worldwide Dietary Guidelines: Efforts So Far and Future Perspectives. Nutrients 2021, 13, 1827. Review.

Marino, M.; Martini, D.; Venturi, S.; Tucci, M.; Porrini, M.; Riso, P.; Del Bo’, C. An Overview of Registered Clinical Trials on Glucosinolates and Human Health: The Current Situation. Front. Nutr. 2021. 8:730906. doi: 10.3389/fnut.2021.730906. Review.

Marino, M., Del Bo′, C., Tucci, M.; Venturi, S.; Mantegazza, G.; Taverniti, V.; Møller, P.; Riso, P.; Porrini, M. A mix of chlorogenic and caffeic acid reduces C/EBPß and PPAR-γ1 levels and counteracts lipid accumulation in macrophages. Eur J Nutr (2021). Article.


Presentations (poster and oral communications):

Tucci Massimiliano, Martini Daniela, Del Bò Cristian, Marino Mirko, Battezzati Alberto, Bertoli Simona, Porrini Marisa, Riso Patrizia. Evaluation of potential nutritional issues associated to a 2000 kcal Mediterranean-adapted planetary diet for Italian population (EAT-IT). Nutrition, metabolism, and cardiovascular diseases: NMCD 31(11):3255-3256. doi: 10.1016/j.numecd.2021.08.023. Oral communication.

Marino Mirko, Tucci Massimiliano, Taverniti Valentina, Riso Patrizia, Porrini Marisa, Klimis-Zacas Dorothy, Del Bo’ Cristian. Role of caffeic and chlorogenic acid in the modulation of cellular fatty acid uptake. Proceedings of the Nutrition Society, 79(OCE2), E486. 2020. doi:10.1017/S0029665120004346. Poster.

Tucci Massimiliano, Marino Mirko, Venturi Samuele, Riso Porrini, Porrini M, Del Bò Cristian. Peonidina-3-glucosie e acido vanillico riducono il processo di adesione dei monociti alle cellule endoteliali e produzione di molecole di adesione. SINU national congress 2019 (Genoa, Italy). Oral communication.

Del Bo’ Cristian, Marino Mirko, Tucci Massimiliano, Riso Patrizia, Porrini Marisa. Effect of caffeic and chlorogenic acid in the modulation of lipid accumulation in THP-1 derived macrophages. 3rd World Congress on Nutrition, Dietetics and Nutraceuticals. 2019 (Prague, Czech Republic). DOI: 10.4172/2472-1921-C1-005. Poster.

Marino Mirko, Porrini Marisa, Tadini Jacopo, Tucci Massimiliano, Riso Patrizia, Del Bo’ Cristian. Ruolo di acido caffeico e clorogenico nella modulazione dell’accumulo dei lipidi in un modello di aterogenesi. SINU national congress 2018 (Naples, Italy). Poster.


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