PhD student profile, Valerio De Vitis

PhD Student:  Valerio De Vitis


Tutor: Prof. Francesco Molinari

Dean: Prof. Francesco Bonomi

Research area: Chemistry and Biochemistry

PhD title achieved on: 21st December 2017


Research topic

Biotechnological processes for the transformation of agri-food residues into value-added molecules


Project Synopsis

In this PhD project we will try to improve the native biotechnological features of acetic acid bacteria (AAB) through the use of recombinant DNA technology. The aim is to study the possibility to use AAB as a “cell factories” to obtain an expression protein system in acetic acid bacteria leading to the preparation of products of industrial interest.


Project keywords

acetic acid bacteria (AAB), biocatalysis, continuous processes, green chemistry



Department of Food, Environmental and Nutritional Sciences (DeFENS) – Via Mangiagalli 25, 20133 Milano




Prof.ssa Paola Conti,  Department of Pharmaceutical Sciences (DISFARM), University of Milan;

Prof.ssa Elisabetta Brenna, Department of Chemistry, Materials and Chemical Engineering, Politecnico of Milano

Prof. Martino Bolognesi,  Department of Biosciences, University of Milan



Fellowship sponsor: Università degli Studi di Milano



Brenna E., Cannavale F., Crotti M., De Vitis V., Gatti F.G., Migliazza G., Molinari F., Parmeggiani F., Romano D., Santangelo S. Synthesis of enantiomerically enriched 2-hydroxymethyl alkanoic acids by oxidative desymmetrisation of achiral 1,3-diols. (2016) In press DOI: 10.1002/cctc.201601051

Contente, M.L., Guidi, B., Serra, I., De Vitis, V., Romano, D., Pinto, A., Lenna, R., de Souza Oliveira, R.P., Molinari, F. Development of a high-yielding bioprocess for 11-α hydroxylation of canrenone under conditions of oxygen-enriched air supply. (2016) Steroids, 116, pp. 1-4. DOI: 10.1016/j.steroids.2016.09.013

Contente, M.L., Serra, I., Brambilla, M., Eberini, I., Gianazza, E., De Vitis, V., Molinari, F., Zambelli, P., Romano, D. Stereoselective reduction of aromatic ketones by a new ketoreductase from Pichia glucozyma. (2016) Applied Microbiology and Biotechnology, 100 (1), pp. 193-201. DOI: 10.1007/s00253-015-6961-y

De Vitis, V., Guidi, B., Contente, M.L., Granato, T., Conti, P., Molinari, F., Crotti, E., Mapelli, F., Borin, S., Daffonchio, D., Romano, D. Marine Microorganisms as Source of Stereoselective Esterases and Ketoreductases: Kinetic Resolution of a Prostaglandin Intermediate. (2015) Marine Biotechnology, 17 (2), pp. 144-152. DOI: 10.1007/s10126-014-9602-z


Proceedings of National and International Conferences

Valerio De Vitis, Paolo Zambelli, Diego Romano, and Francesco Molinari.(2015) Biocatalysis in seawater. Biotrans 2015, july 26-30 2015 Vienna(poster)

Valerio De Vitis, Lucia Tamborini, Diego Romano, Elisabetta Brenna, Michele Crotti and Francesco Molinari.(2016). Desymmetrization of achiral 2-alkyl-1,3-diols by microbial oxidation and development of a flow-based strategy for its continuous application. GRC 2016, July 10-15 2016 University of New England Biddeford, ME (poster)



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